Acts 13:4,5 - Joseph Benson’s Commentary on the Old and New Testaments

So they being sent forth by the Holy Ghost By his immediate direction. This seems to be added to signify, that though they were solemnly recommended to God by the prayers of their brethren, their authority was not derived from them, but from the Holy Spirit himself. Departed unto Seleucia A considerable port on the Mediterranean sea; and from thence they sailed to Cyprus The island so infamous for the worship of Venus, who was supposed to hold her peculiar residence there, and therefore was commonly called the Cyprian goddess. When they were at Salamis Situated on the eastern part of the island, and consequently was nearest to the place from whence they came; they preached the word in the synagogues of the Jews For there were great numbers of that people in Cyprus. They had also John for their minister Who willingly waited on them, not pretending to a character by any means equal to theirs.