In this verse we find the first mention of Adam in the story of this chapter. No question, the murder of Abel, and the impenitency and apostacy of Cain, were a very great grief to him and Eve and the more because their own wickedness did now correct them, and their backsliding did reprove them. Their folly had given sin and death entrance into the world; and now they smarted by it, being, by means thereof, deprived of both their sons in one day, Genesis 27:45. When parents are grieved by their children's wickedness, they should take occasion from thence to lament that corruption of nature which was derived from themselves, and which is the root of bitterness. But here we have that which was a relief to our first parents in their affliction; namely, God gave them to see the rebuilding of their family, which was sorely shaken and weakened by that sad event. For they saw their seed, another instead of Abel. And Adam called his name Seth That is, set, settled, or placed, because in his seed mankind should continue to the end of time.
Related Commentaries of Genesis 4:25
Genesis 4:25
25 And Adam knew his wife again; and she bare a son, and called his name Seth:h For God, said she, hath appointed me another seed instead of Abel, whom Cain slew.