He therefore that despiseth - Margin, “rejecteth.” That is, he who disregards such commands as these which call him to a holy life, is really rejecting and disobeying God. Some might be disposed to say that these were merely the precepts of man, and that therefore it was not important whether they were obeyed or not. The apostle assures them in the most solemn manner, that, though communicated to them by man, yet they were really the commands of God.
Who hath also given unto us his holy Spirit - This is a claim to inspiration. Paul did not give these commands as his own, but as taught by the Spirit of God; compare notes on 1 Corinthians 7:40.