And when they opposed themselves - To him and his message.
And blasphemed - See the notes on Acts 13:45.
He shook his raiment - As an expressive act of shaking off the guilt of their condemnation. Compare Acts 13:45. He shook his raiment to show that he was resolved henceforward to have nothing to do with them; perhaps, also, to express the fact that God would soon slake them off, or reject them (Doddridge).
Your blood ... - The guilt of your destruction is your own. You only are the cause of the destruction that is coming upon you. See the notes on Matthew 27:25.
I am clean - I am not to blame for your destruction. I have done my duty. The gospel had been fairly offered and deliberately rejected; and Paul was not to blame for their ruin, which he saw was coming upon them.
I will go ... - See Acts 13:46.