I know that ye all - Perhaps this means simply, “I have no expectation of seeing you again; I have every reason to suppose that this is my final interview with you.” He expected to visit Ephesus no more. The journey to Jerusalem was dangerous. Trials and persecutions he knew awaited him. Besides, it is evident that he designed to turn his attention to other countries, and to visit Rome; and probably he had already formed the purpose of going into Spain. See Acts 19:21; compare Romans 15:23-28. From all these considerations it is evident that he had no expectation of being again at Ephesus. It is probable, however, that he did again return to that city. See the notes on Acts 28:31.
Among whom I have gone preaching - Among whom I have preached. The parting of a minister and people is among the most tender and affecting of the separations that occur on earth.
The kingdom of God - Making known the nature of the reign of God on earth by the Messiah. See the notes on Matthew 3:2.