Sirs - Greek: Men.
I perceive - It is not certain that Paul understood this by direct inspiration. He might have perceived it from his own knowledge of the danger of navigation at the autumnal equinox, and from what he saw of the ship as unsuited to a dangerous navigation. But there is nothing that should prevent our believing also that he was guided to this conclusion by the inspiration of the Spirit of God. Compare Acts 27:23-24.
Will be with hurt - With injury or hazard. It is not meant that their lives would be lost, but that they would be jeoparded.
The lading - The freight of the ship. It was laden with wheat, Acts 27:38. Paul evidently, by this, intended to suggest the propriety of remaining where they were until the time of dangerous navigation was past.