Compare the marginal reference. The prohibition of Deuteronomy 22:10 was also dictated by humanity. The ox and the donkey being of such different size and strength, it would be cruel to the latter to yoke them together. These two animals are named as being those ordinarily employed in agriculture; compare Isaiah 32:20.
Related Commentaries of Deuteronomy 22:9
Deuteronomy 22:9-11
9 Thou shalt not sow thy vineyard with divers seeds: lest the fruit of thy seeda which thou hast sown, and the fruit of thy vineyard, be defiled.
10 Thou shalt not plow with an ox and an ass together.
11 Thou shalt not wear a garment of divers sorts, as of woollen and linen together.