At that day shall a man look to his Maker - Instead of confiding in their strongly fortified places and armies, they shall look for aid and protection to the God that made them, and who alone can help them. National afflictions and judgments often have the effect to turn the eyes of even a wicked and rebellious people to God. They feel their danger; they are convinced of their guilt; they see that no one but God can protect them; and for a time they are willing, even by humiliation and fasting, to seek the divine protection.
His eyes shall have respect ... - He shall look up to, or regard.
The Holy One of Israel - The God of Israel; the true God. As the Syrians were allied with the kingdom of Samaria or Ephraim, they were, of course, acquainted with the true God, and in some sense acknowledged him. In these times of impending calamity, they would be led to seek him, and implore his aid and protection. There is no reason to believe, however, that they would turn permanently to him, or become his true worshippers.