Against ... - i. e., relating to, concerning. So Jeremiah 48:1; Jeremiah 49:1; see the note at Jeremiah 46:13.
Pharaoh-necho - See 2 Kings 23:29 note.
In - (at) Carchemish - (The Gargamis of the inscriptions, now Jerabis, on the Euphrates, about 16 miles south of Birejik.)