How long will ye vex my soul? - Perhaps designing to reply to the taunting speech of Bildad; Job 18:2. “He” had asked “how long it would be ere Job would make an end of empty talk?” “Job” asks, in reply, “how long” they would torture and afflict his soul? Or whether there was on hope that this would ever come to an end!
And break me in pieces - Crush me, or bruise me - like breaking any thing in a mortar, or breaking rocks by repeated blows of the hammer. “Noyes.” He says they had crushed him, as if by repeated blows.