Shall any teach God knowledge? - This commences the reply of Job to the sentiments of his friends to which he had just adverted. The substance of the reply is, that no one could prescribe to God how he should deal with people, and that it; was not a FACT that people were treated as they had supposed. Instead of its being true, as they maintained, that wicked people would all be cut down in some fearful and violent manner, as a punishment for their sins, Job goes on Job 21:23-26 to show that they died in a great variety of ways - one in full age and prosperity, and another in another manner. This, he says, God directs as he pleases. No one can teach him knowledge; no one can tell him what he ought to do. The reasoning of his friends, Job seems to imply, had been rather an attempt to teach God how he “ought” to deal with people, than a patient and candid inquiry into the “facts” in the case, and he says the facts were not as they supposed they ought to be.
Seeing he judgeth those that are high - Or rather, he judges “among the things” that are high. He rules over the great affairs of the universe, and it is presumptuous in us to attempt to prescribe to him how he shall govern the world. The design of this and the following verses is to show, that, from the manner in which people actually die, no argument can be derived to determine what was their religious condition, or their real character. Nothing is more fallacious than that kind of reasoning.