Is not my help in me? - This would be better rendered in an affirmative manner, or as an exclamation. The interrogative form of the previous verses need not be continued in this. The sense is, “alas! there is no help in me!” That is, “I have no strength; I must give up under these sorrows in despair.” So it is rendered by Jerome, Rosenmuller, Good, Noyes, and others.
And is wisdom quite driven from me? - This, also, should be read as an affirmation, “deliverance is driven from me.” The word rendered wisdom (תשׁיה tûshı̂yâh) means properly a setting upright; then help, deliverance; and then purpose, enterprise; see the notes at Job 5:12. Here it means that all hope of deliverance had fled, and that he was sinking in despair.