Let them curse, but bless thou - See Psalms 109:17. Let them continue to curse me, provided thou wilt bless me. I am willing to bear all these reproaches, if I may have thy favor. That favor I value infinitely more than I do theirs; and it is a small matter that I am reviled and cursed by people, if I may secure the favor and friendship of God.
When they arise - When they rise up against me; when they attempt to persecute me.
Let them be ashamed ... - Let them be disappointed; let them not be successful in their designs against me. On the word “ashamed,” see Job 6:20, note; Psalms 25:2-3, note.