But I am a worm, and no man - In contrast with the fathers who trusted in thee. They prayed, and were heard; they confided in God, and were treated as men. I am left and forsaken, as if I were not worth regarding; as if I were a grovelling worm beneath the notice of the great God. In other words, I am treated as if I were the most insignificant, the most despicable, of all objects - alike unworthy the attention of God or man. By the one my prayers are unheard; by the other I am cast out and despised. Compare Job 25:6. As applicable to the Redeemer, this means that he was forsaken alike by God and men, as if he had no claims to the treatment due to a “man.”
A reproach of men - Reproached by men. Compare Isaiah 53:3, and the notes at that verse.
Despised of the people - That is, of the people who witnessed his sufferings. It is not necessary to say how completely this had a fulfillment in the sufferings of the Saviour.