Saying, God hath forsaken him - That is, God has given him over; he no longer protects him; he regards him as a wicked man, and we shall therefore, not only be “safe” in our attempts upon his life, but we shall be “justified” in those attempts.
Persecute and take him - It can be done safely now; it can be done with propriety.
For there is none to deliver him - He has no one now to whom to look; no one on whom he can rely. Abandoned by God and by man, he will be an easy prey. Compare the notes at Psalms 41:7-8.