Deliver me, O my God, out of the hand of the wicked - It is, of course, not possible now to ascertain who are particularly referred to here. If David was the author of the psalm, they may have been any of the numerous enemies that he had in his life.
Out of the hand of the unrighteous and cruel man - Hebrew, “out of the palm.” This means here the same as hand, and refers to the “grasp” which anyone makes in taking hold of a thing by the hand.