Genesis 4:11,12 - Ellicott's Commentary On The Whole Bible

And now (because of thy crime) art thou cursed from the earth. — Heb., from the adâmâh, or cultivated ground. Cain was the first human being on whom a curse was inflicted, and it was to rise up from the ground, the portion of the earth won and subdued by man, to punish him. He had polluted man’s habitation, and now, when he tilled the soil, it would resist him as an enemy, by refusing “to yield unto him her strength.” He had been an unsuccessful man before, and outstripped in the race of life by the younger son; for the future his struggle with the conditions of life will be still harder. The reason for this follows: “a fugitive and a vagabond shalt thou be in the earth.” Restless and uneasy, and haunted by the remembrance of his crime, he shall become a wanderer, not merely in the adâmâh, his native soil, but in the earth. Poverty must necessarily be the lot of one thus roaming, not in search of a better lot, but under the compulsion of an evil conscience. Finally, however, we find that Cain’s feelings grew more calm, and being comforted by the presence of a wife and children, “he builded a city,” and had at last a home.