For lack of knowledge, which you, O priest, should have kept alive in their hearts. The knowledge of God is life eternal. (Comp. John 17:3.) The Lord’s “controversy” repudiates the entire priesthood, as they had rejected the true knowledge of God. They had inclined to calf-worship, had been vacillating respecting Baal, and had connived at moral offences. If, on the other hand, with most commentators, we consider the people themselves as thus addressed, the passage refers to the cessation of the position of priesthood, which every member of the true theocracy ought to have maintained. (Comp. Exodus 19:6.) The people should no longer be priests to Jehovah.
Related Commentaries of Hosea 4:6
Hosea 4:6
6 My people are destroyedc for lack of knowledge: because thou hast rejected knowledge, I will also reject thee, that thou shalt be no priest to me: seeing thou hast forgotten the law of thy God, I will also forget thy children.