Vanity — i.e., calamity, trouble.
The rod of his anger shall fail. — When his time comes, and his iniquity is full, he shall himself suffer the punishment he brought on others, as Babylon did (Isaiah 14:6), Assyria (Isaiah 30:31).
Related Commentaries of Proverbs 22:8
Proverbs 22:8
8 He that soweth iniquity shall reap vanity: and the rodd of his anger shall fail.