The Desert of the Sea can mean no other than Babylon; and the ruin of it is foretold by way of comforting God's people in their captivity. It is blessed to observe, how beforehand the Lord is for his people, in laying in comforts again a time of tribulation; Elam and Media, that is, Persia and the Medes, were to conquer Babylon; and therefore, when the church in her captivity found that the Medians were come to besiege Babylon, the recollection of this prophecy might give them comfort: for in the ruin of Babylon, would be their deliverance. Daniel 5:31.
Related Commentaries of Isaiah 21:1
Isaiah 21:1-2
1 The burden of the desert of the sea. As whirlwinds in the south pass through; so it cometh from the desert, from a terrible land.
2 A grievousa vision is declared unto me; the treacherous dealer dealeth treacherously, and the spoiler spoileth. Go up, O Elam: besiege, O Media; all the sighing thereof have I made to cease.