over much: i.e. depending on the merit of good works.
over wise: i.e. beyond what is necessary.
destroy thyself. make thyself lonely: i.e. forsaken. Compare Job 16:7.
Related Commentaries of Ecclesiastes 7:16
Ecclesiastes 7:16
16 Be not righteous over much; neither make thyself over wise: why shouldest thou destroyg thyself?