friends. kinsfolk. "His brethren, and His mother" (see Mark 3:31).
went out. set out.
they said. they were saying (Imperf. Tense): i.e. maintained (as we say).
beside Himself. out of His senses.
Related Commentaries of Mark 3:21
Mark 3:21
21 And when his friendsd heard of it, they went out to lay hold on him: for they said, He is beside himself.