In the flesh; i.e. in the body, meaning his natural life: flesh is here taken in a third sense, different from the two former: so Galatians 2:20 Philippians 1:22. By the lusts of men, he means the corrupt desires and sinful ways of carnal men, to which they were not to conform themselves, or make them the rule of their living, Romans 12:2 1 Corinthians 3:3 Colossians 2:8 Titus 1:14. But to the will of God; the holy will of God revealed to us in his law, (which is the rule by which we are to walk), in opposition to the lusts of men; we are to live not as men would have us, but as God commands us.
Related Commentaries of 1 Peter 4:2
1 Peter 4:2
2 That he no longer should live the rest of his time in the flesh to the lusts of men, but to the will of God.