Colossians 3:2 - Matthew Poole's English Annotations on the Holy Bible

Set your affection on things above: that the hearts of believers here might be where their treasure is, the apostle here repeats his exhortation, using another word, importing they should intensely mind things above, Romans 8:5, viz. the inheritance reserved in heaven for us, 1 Peter 1:4, with heart and affections, together with all that Gcd hath appointed to be a furtherance to the enjoyment of it; not curiously to search the deep things of God, which cannot be found out, but to mind things above with sobriety, Romans 12:3. Not on things on the earth; taking off the mind and heart from all that is opposite to heavenly things, viz. not only those human, carnal ordinances and ceremonies, Colossians 2:22, with Philippians 3:18,19, but also from the eager pursuit of the pleasures, profits, and honours of this world, which the men of it do inordinately desire, Colossians 3:5, with Matthew 6:33 Galatians 5:24, and are carried away with, Titus 2:12 James 4:4 2 Peter 1:4 1 John 2:17. Christians should not be, to the neglect of things spiritual; however, they are obliged, in a due subordination, to take care of themselves and families for these things below, so far as to put them into a capacity of raising them more heavenward.