With it, to wit, with the passover, in the sense delivered; or, in it, i.e. during the time of the feast of the passover. The bread of affliction, i.e. bread which is not usual nor pleasant, but unsavoury and unwholesome, to put thee in mind both of thy miseries endured in Egypt, and of thy hasty coming out of it, which allowed thee no time to leaven or to prepare thy bread.
Related Commentaries of Deuteronomy 16:3
Deuteronomy 16:3
3 Thou shalt eat no leavened bread with it; seven days shalt thou eat unleavened bread therewith, even the bread of affliction; for thou camest forth out of the land of Egypt in haste: that thou mayest remember the day when thou camest forth out of the land of Egypt all the days of thy life.