The wisdom of thy God that is in thine hand, i.e. which God hath put into thy heart, and which appears in the works of thy hand. Wisdom is sometimes ascribed to the hands, as Psalms 78:72. See my Latin Synopsis on Genesis 48:14. Or, by the wisdom of God, he means the law of God, which was said to be in his hand, Ezra 7:14.
Related Commentaries of Ezra 7:25
Ezra 7:25
25 And thou, Ezra, after the wisdom of thy God, that is in thine hand, set magistrates and judges, which may judge all the people that are beyond the river, all such as know the laws of thy God; and teach ye them that know them not.