Those that are friends or enemies to thee shall be the same to me; a marvellous condescension and privilege. In thee, i.e. in thy Seed, as it is explained Genesis 22:18, Genesis 26:4 28:14, i.e. in and through Christ, Acts 3:25 Galatians 3:9,16,28,29; or, for thee, as the Chaldee hath it, i.e. for thy sake; or, by thee, i.e. by thy means; or, with thee, by comparing this with Galatians 3:8,9, i.e. in the same way and manner in which thou art blessed, that is, by a fruitful faith: compare Romans 4:11,12,16. All families of the earth, i.e. all nations; which is to be limited to the believers of all nations, by the whole current of the Scriptures. All that shall be blessed shall be blessed by this means, and no other way.
Related Commentaries of Genesis 12:3
Genesis 12:3
3 And I will bless them that bless thee, and curse him that curseth thee: and in thee shall all families of the earth be blessed.