Genesis 5:22 - Matthew Poole's English Annotations on the Holy Bible

i.e. He lived as one whose eye was continually upon God; whose care and constant course and business it was to please God, and to imitate him, and to maintain acquaintance and communion with him; as one devoted to God's service, and wholly governed by his will. He walked not with the men of that wicked age, or as they walked, but being a prophet and preacher, as may be gathered from Judges 1:14-15, with great zeal and courage he protested and preached against their evil practices, and boldly owned God and his ways in the midst of them. Compare Genesis 6:6 Jeremiah 12:3 Micah 6:8. Begat sons and daughter s; hence it is undeniably evident that the state and use of matrimony doth very well agree with the severest course of holiness, and with the office of a prophet or preacher.