From Assyria; as there was another highway from Egypt in the former verse. So the sense is, that all impediments shall be removed, and a way made for the return of God's Israel from all parts of the world. He mentions Assyria, because thither the ten tribes were carried, 2 Kings 17:23; whose case seemed to be most desperate.
Related Commentaries of Isaiah 11:16
Isaiah 11:16
16 And there shall be an highway for the remnant of his people, which shall be left, from Assyria; like as it was to Israel in the day that he came up out of the land of Egypt.