The treaders: in those times they used to squeeze out the juice of their grapes by treading them with their feet, in vessels appointed for that use, Judges 9:27 Nehemiah 13:15.
Related Commentaries of Isaiah 16:10
Isaiah 16:10
10 And gladness is taken away, and joy out of the plentiful field; and in the vineyards there shall be no singing, neither shall there be shouting: the treaders shall tread out no wine in their presses; I have made their vintage shouting to cease.