That are mighty to drink wine; that can drink much without intoxication, in which they gloried, as too many do at this day. To mingle, i.e. to drink; the antecedent being put for the consequent, which is usual; for they mingled it in order to drinking.
Related Commentaries of Isaiah 5:22
Isaiah 5:22
22 Woe unto them that are mighty to drink wine, and men of strength to mingle strong drink: