Isaiah 64:6 - Matthew Poole's English Annotations on the Holy Bible

We are all as an unclean thing: he alludes either to things unclean under the ceremonial law, wherein the leprosy was found, and was to be burnt, Leviticus 13:55; or rather to persons unclean. They compare their present state with the former: q.d. Formerly there were some that feared thee, and walked uprightly before thee, and were in thy favour; but now we are all as one polluted mass, nothing of good left in us, by reason of a universal degeneracy, Isaiah 1:4,6. Our righteousnesses: this, according to the most commentators, refers either to the observances of the rites and ceremonies of the law, wherein they thought their righteousnesses did much consist; or to the best work and actions that can be performed by us; or to our natural, universal depravities: but the best interpreters, and such aim at the peculiar sense of the place, refer it to the gross provocations that this people were guilty of, causing God to cast them out of their habitations; or else to their persons, i.e. the most righteous among us; and being plural, it raiseth it up to the highest degree, the Scripture frequently putting the abstract for the concrete, as wisdoms for the greatest wisdom, Proverbs 9:1, and many the like instances formerly given; so that the meaning is, the very best of us all are no better than the uncleanest things or persons; see Micah 7:2-4; and the rather, because he lived about the time of Isaiah. As filthy rags; a cloth made up of patches, or such as come from a putrid sore, or defiled with the menstruous blood of a woman; the LXX., as a rag of one that sits down, possibly alluding to Rachel, Genesis 31:34,35, or whatever may be most filthy. As a leaf blown off the tree, and so withers. Taken us away; carried us away to Babylon from our habitations, as leaves hurried away by a boisterous wind; our iniquities have been the procuring cause.