Dedan was the son of Jokshan, 1 Chronicles 1:32, from which it is probable that the city Dedan had its name; it is reckoned, Jeremiah 25:23, with Tema and Buz, and is mentioned Ezekiel 27:15,20 Ezekiel 38:13. It was a city of Arabia joining on Idumea, Isaiah 21:13. They being neighbours to the Edomites, are called to flee, and to get into caves and holes of the earth, where they might dwell deep in the earth, and be in some security, which they would not be in their own city, so near to the Edomites country, for God was resolved to bring misery upon the Edomites, a time of calamity in which he would visit them with his judgments. There are other critical readings of these words, but this seemeth to be the plain sense of them.
Related Commentaries of Jeremiah 49:8
Jeremiah 49:8
8 Flee ye, turn back, dwell deep, O inhabitants of Dedan; for I will bring the calamity of Esau upon him, the time that I will visit him.