The substance of both these verses is, that Babylon should be totally ruined, as Sodom and Gomorrah, so as there should be no habitations for men, but wild beasts only of all sorts should inhabit and lodge in it. The fulfilling of this we have not in holy writ, only the beginning of its accomplishment, it being taken by Cyrus, who only made them tributaries, and took away their government. But they rebelling against the emperor of the Medes, Darius Hystaspes, a succeeding emperor, pulled down their walls. And about two hundred and fifty years after Seleucus Nicenor, a Grecian prince, the Medes being before conquered by Alexander the Great, utterly destroyed Babylon, so as in the time of Hadrian the Roman emperor there was nothing left standing of that great city but some pieces of walls.
Related Commentaries of Jeremiah 50:40
Jeremiah 50:40
40 As God overthrew Sodom and Gomorrah and the neighbour cities thereof, saith the LORD; so shall no man abide there, neither shall any son of man dwell therein.