Runneth upon him, i.e. assaults him, or rusheth upon him with great swiftness and fury, as this phrase signifies, Daniel 8:6. This he is either,
1. God, who was expressed twice in the last verse, and who is here produced as entering the lists and fighting with his daring adversary. Or rather,
2. The wicked man, of whom and whose sin and misery he speaks in the whole context, both before and after this; who in the last verse was introduced as preparing for the battle, and here as actually and impudently fighting with him. Even on his neck; as a stout warrior, who cometh close to his adversary and grapples with him, and taketh him by the neck to throw him down. Compare 2 Samuel 2:16 Job 16:2. Or, with his neck. So it is a metaphor from a mad and raging bull, which runs upon his enemy with a hard and stiff neck. Upon the thick bosses of his bucklers, i.e. even where his enemy is strongest; he is not discouraged with the enemies thick, and strong, and eminent shields, but boldly ventures in upon them, and amongst them. Or, with the thick bosses (Heb. the thickness and eminency) of his shields, wherewith he invaded the enemy, that so he might both defend himself and offend his enemy; for the ancient shields were useful both ways, because they had a sharp iron or steel in the midst of them.