How, and in what sense, trouble of spirit could agree to Christ, was noted before, 1 Thessalonians 12:27: see the notes on that text. This seemeth to have been rather a trouble of grief, that one of his apostles, one whom he had chosen, should commit so great a villany, than arising from fear of death; for his next words are a further discovery of the person that should betray him: he had said before, that he should be betrayed, and that it should be by one that used to eat bread with him; but now he cometh closer, and tells them that it should be by one of them, that is, one of the twelve; this was a closer discovery than he had as yet made.
Related Commentaries of John 13:21
John 13:21
21 When Jesus had thus said, he was troubled in spirit, and testified, and said,Verily, verily, I say unto you, that one of you shall betray me.