Men and women may be in the world, yet not of the world. Of the world here signifies carnal men, such as are like to the men of the world in their studies, designs, counsels, affections; as of the devil, and of God, signifies, 1 Thessalonians 8:44,47. If you had affections, lusts, and dispositions like them, and drove no other designs than they drive, you might expect, that as it is of the nature of all men to love such as are like to them in manners and studies; so they would love you, take a delight in you, be kind to you, and do you all offices of love: but because you are not of such tempers, dispositions, and inclinations; but that I, having chosen you out of the world, have given you new hearts, new frames and dispositions, quite contrary to theirs; therefore the world, disliking you, and seeing that your principles are quite opposite to theirs, abhor and hate you, and will be ready to do you all that evil and mischief, which is the product of a rooted hatred and malice in the heart. This is a second argument by which our Lord comforts them. It is drawn from the cause and root of that hatred which they would meet with: it was not for their faults or sins, but because they were the objects of Christ's love, which being also shed abroad in their hearts by the Holy Ghost, produced again in them holy affections and dispositions, making them wholly unlike to men in the world.
Related Commentaries of John 15:19
John 15:19
19 If ye were of the world, the world would love his own: but because ye are not of the world, but I have chosen you out of the world, therefore the world hateth you.