Christ spake those words more than once, Matthew 13:57 Mark 6:4 Luke 4:24. But the question is, what force of reason this hath why he went into Galilee, whereas Nazareth, which was in Galilee, was his own country; for though he was born in Bethlehem, yet he was educated at Nazareth; upon which account, Luke 4:23, it is called his own country? The best resolution of this difficulty is, that by Galilee here is to be understood, the country part of Galilee, exclusive to Nazareth; and this is not given as a reason why our Saviour went into Galilee, but why he did not go to Nazareth, but into the country part of Galilee, because Nazareth was his own country, and a prophet is not without honour, except in his own country.
Related Commentaries of John 4:44
John 4:44
44 For Jesus himself testified, that a prophet hath no honour in his own country.