The ten tribes were all carried captives into Assyria, many of the kingdom of Judah, as we have heard, fled into Egypt after the taking of Jerusalem. Giving the hand may either signify working with their hands, and labouring for them; or yielding up themselves to their power, or lifting up the hands as supplicants to them, or striking hands and making covenants with them, or lending them their hand, to help them, and all to get any thing to live upon.
Related Commentaries of Lamentations 5:6
Lamentations 5:6
6 We have given the hand to the Egyptians, and to the Assyrians, to be satisfied with bread.