These words seem to relate singly to the destruction of Jerusalem. See Poole on "Matthew 24:17", See Poole on "Matthew 24:18", where we had the same. They only signify the certain ruin and destruction of the place, and are our Saviour's counsel to his disciples, not to linger, or promise themselves any longer security there, notwithstanding what any false Christs or false prophets should plainly tell them, but to make as much haste away out of it as they possibly could.
Related Commentaries of Luke 17:31
Luke 17:31
31 In that day, he which shall be upon the housetop, and his stuff in the house, let him not come down to take it away: and he that is in the field, let him likewise not return back.