Lord, what is man he aggravates God's goodness to him, expressed Psalms 144:2, by the consideration of his own meanness. Though I am king over my people, yet, alas, I am but a man. a base, sinful, mortal, and miserable creature; if compared with thee, less than nothing and vanity. Takest knowledge of him, i.e. hast any care and kindness for him, as words of knowledge commonly imply in Scripture. Makest account of him; the same thing repeated in other words.
Related Commentaries of Psalms 144:3
Psalms 144:3
3 LORD, what is man, that thou takest knowledge of him! or the son of man, that thou makest account of him!