Psalms 22:30 - Matthew Poole's English Annotations on the Holy Bible

Christ shall not want a seed or posterity, Hebrews 2:13; for though the Jewish nation should generally reject and forsake him, which may seem to be here implied, Christ shall have many disciples or followers, and the Gentiles shall come in their stead. Compare this promise with that, he shall see his seed, Isaiah 53:10. Or, their seed, i.e. the seed of the Gentile worshippers last mentioned. Christian religion shall not be the business of one age, but, as the Gentiles shall believe in Christ, so shall their posterity in succeeding generations; this being God's usual method, to take children into covenant with their parents, of which see Deuteronomy 10:15, Deuteronomy 30:19 Psalms 69:36 Isaiah 43:5, Isaiah 44:3. And as when the Jews refused Christ, their children were cast out of the covenant with them; so when the Gentiles embraced the gospel covenant, their children were admitted with them. It shall be accounted to the Lord for a generation; that believing seed shall be reputed, both by God and men, the generation, or children, or people of the Lord, as the Jews formerly were. But upon the Jews contempt of Christ and the gospel, the Gentiles shall come in their stead, and enjoy their titles and privileges. Compare this place with Psalms 87:5.