Notwithstanding all these fine fancies and devices man being in honour, living in all the splendour and glory above mentioned, abideth not. The Hebrew word properly signifies to lodge for a night, as Genesis 32:21 Judges 19:10; and thence to abide for a long or considerable time, as Psalms 25:13, Psalms 55:7 Proverbs 15:31. All his dreams of perpetuating his name and estate shall vanish and be confuted by experience. That perish, i.e. that are utterly lost and extinct. So he is in reference to all his wealth and honour, of which he here speaks.
Related Commentaries of Psalms 49:12
Psalms 49:12
12 Nevertheless man being in honour abideth not: he is like the beasts that perish.