Revelation 12:13 - Matthew Poole's English Annotations on the Holy Bible

And when the dragon saw that he was cast unto the earth; when the devil saw that he could not uphold his kingdom by paganism, nor further execute his malice by pagan emperors, but was wholly routed and overcome, as to that power. He persecuted the woman which brought forth the man-child; to let us know that he retained his malice, though he had lost his former power, he goes on in pursuing the church of God to its ruin, only doth it in another form; heretofore in the form of a pagan, now under the pretence of a Christian; by heretics, the spawn of Arius and Photinus, (who were before this time), and by Pelagius, Nestorius, and Eutyches, who all were between the years 400 and 500, and by antichrist, the beast we shall read of, Revelation 13:1, with seven heads and ten horns.