And heard another voice from heaven, saying: a command from God. Come out of her, my people: they are the words of God by his prophet, Jeremiah 50:8, Jeremiah 51:6, calling to his people, that the years of their captivity being now expired, and they having a liberty to go back to Jerusalem, they would not linger longer in Babylon, nor partake of her sins; for God was about to destroy that place; and if they were found in it, they would be in danger of being destroyed with it, especially if they were found partakers of its sins. But they are also a general warning to all to take heed of any fellowship with idolaters; and so the apostle applieth part of these words, 2 Corinthians 6:17. Here they are applied to mystical Babylon, which is Rome antichristian. God calls to all that either love him, or their own souls, to forsake the commmion of it; for while they continue in it, they must partake of its sins, worshipping the beast, by paying, at his command, a Divine homage to saints and angels, to the virgin Mary, to images and statues, nay, to a piece of baker's bread; and doing so, they will be involved in her plagues. This text looks terribly upon those who apostatize to that idolatry; and instead of coming out, (in obedience to the command of God), being come out, go in again, and that not by compulsion, but out of choice, and voluntarily.
Related Commentaries of Revelation 18:4
Revelation 18:4
4 And I heard another voice from heaven, saying, Come out of her, my people, that ye be not partakers of her sins, and that ye receive not of her plagues.