1 Corinthians 12:22 - Coke's Commentary on the Holy Bible

Nay, much more those members, &c.— Some think that in the words which seem to be more feeble, St. Paul refers to the brains and bowels, which are very tender, and liable to many disorders. Others understand it of the least muscular parts, veins, arteries, and other minute channels in the body, the least obstruction in some of which would be fatal. If more feeble be put for less noble, it suggests a very obviousandimportantsense,relatingtothechannelsnaturehasprovided for throwing off the dregs, which, dishonourable as they may seem, are so necessary, that if they be obstructed, intense torment and inevitable death must ensue. Doddridge.