2 Timothy 3:3 - Coke's Commentary on the Holy Bible

Without natural affection— The word Στοργη, signifies that natural affection which even the brute creatures, as well as men, manifest, in cherishing, feeding, and taking care of their young ones; and the word αστοργοι signifies persons divested of that natural tenderness. The apostle does not mean that God would not implant such a principle in those apostates, as well as in other men; but that they would, by their cruelty and other wickedness, do all they could to root it out; or at least they would refuse to act as such a principle would dictate. The word ασπονδοι, rendered truce-breakers, signifies not only implacable, but treacherous persons; and may be applied to men, who, when once offended, will come to no treaty of reconciliation;—and also to those, who will not think themselves bound by such treaties, when they may accomplish any purposes of their own by a violation of them.