Leave thy fatherless children— This is understood by many to be an irony. See Isaiah 16:4. But there is nothing in the context, says Houbigant, which can lead to this interpretation. I rather understand it as a prophesy; nor was it any thing wonderful that the conquerors should spare the little children and widows, from whom they had nothing to fear; nor that the Edomites should forsake both the one and the other, when compelled to a precipitate flight.
Related Commentaries of Jeremiah 49:11
Jeremiah 49:11
11 Leave thy fatherless children, I will preserve them alive; and let thy widows trust in me.