Psalms 141:2 - Coke's Commentary on the Holy Bible

Let my prayer, &c.— This shews the writer at a distance from the tabernacle; where all their solemn prayers, together with their daily sacrifices, were offered up; and therefore, with his face probably directed thither, he begs that God would accept of all that was in his power to perform: namely, the devotion of his heart, and the elevation of his hands in prayer: as if he had said, "Though this address of mine must necessarily want all those solemnities of preparation required in the service of thy holy tabernacle; yet let the purity and fervour of my heart, and the innocency of my hands now lifted up to thee, in this sad hour of my distress, be accepted instead of these, and prevail for deliverance and a safe retreat to me and my companions."