I am shut up, and I cannot come forth— This is the description of a person confined for leprosy, which causes him to be avoided, as a subject of abhorrence even to all his friends.
Related Commentaries of Psalms 88:8
Psalms 88:8
8 Thou hast put away mine acquaintance far from me; thou hast made me an abomination unto them: I am shut up, and I cannot come forth.